HPV Vaccine Recommendations

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More than 15 years of data show that HPV vaccination provides safe, effective, and long-lasting protection against cancers caused by HPV infections. Research shows that healthcare professionals are parents’ most trusted source of information about the HPV vaccine.

CDC encourages healthcare professionals to recommend HPV vaccination in the same way and on the same day that they recommend other vaccines for adolescents.

This page summarizes CDC's current HPV vaccine recommendations. Access the official, full text below:

ACIP Recommendations on HPV and other MMWR articles. Advisory Committee on Immunization Practices (A.

Routine recommendations

Keep in mind‎

HPV vaccination prevents new HPV infections but does not treat existing HPV infections or diseases. HPV vaccine works best when given before any exposure to HPV.

• HPV vaccine is recommended for routine vaccination at 11 or 12 years old. Vaccination can be started at age 9.
• ACIP also recommends vaccination for everyone through age 26 years if not adequately vaccinated when younger. HPV vaccination is given as a series of either two or three doses, depending on age at initial vaccination.
• Vaccination is not recommended for everyone older than age 26 years. Some adults ages 27 through 45 years might decide to get the HPV vaccine based on discussion with their clinician, if they did not get adequately vaccinated when they were younger. HPV vaccination of people in this age range provides less benefit, for several reasons, including that more people in this age range have already been exposed to HPV.
• For adults ages 27 through 45 years, clinicians can consider discussing HPV vaccination with people who are most likely to benefit. HPV vaccination does not need to be discussed with most adults over age 26 years. See ACIP’s shared clinical decision-making FAQs.

Most sexually active adults have already been exposed to HPV, although not necessarily all of the HPV types targeted by vaccination. At any age, having a new sex partner is a risk factor for getting a new HPV infection. People who are in a long-term, mutually monogamous relationship are not likely to get a new HPV infection.

Dosing schedule

Two doses of HPV vaccine are recommended for most people starting the series before their 15th birthday.

• The second dose of HPV vaccine should be given 6 to 12 months after the first dose.
• Adolescents who receive two doses less than 5 months apart will require a third dose of HPV vaccine.

Three doses of HPV vaccine are recommended for teens and young adults who start the series at ages 15 through 26 years, and for immunocompromised persons.

• The recommended three-dose schedule is 0, 1–2 months, and 6 months.
• Three doses are recommended for immunocompromised persons (including those with HIV infection) aged 9 through 26 years.

Vaccine safety

HPV vaccines are very safe. Scientific research shows the benefits of HPV vaccination far outweigh the potential risks. Like all medical interventions, vaccines can have some side effects.

All vaccines used in the United States, including HPV vaccines, go through extensive safety testing before the U.S. Food and Drug Administration (FDA) licenses them. During clinical trials before the licensure, the 9-valent HPV vaccine Gardasil 9 was studied in more than 15,000 males and females and was found to be safe and effective.

Possible adverse reactions

No serious adverse events have been associated with any HPV vaccine. Ongoing monitoring is conducted by CDC and the Food and Drug Administration.

Syncope (fainting) can occur after any medical procedure, including vaccination. Adolescents should be seated or lying down during vaccination and remain in that position for 15 minutes after vaccination. This is to prevent any injuries that could occur from a fall during a syncopal event.

The most common adverse reactions reported during clinical trials of HPV vaccines were local reactions at the site of injection. In prelicensure clinical trials, local reactions such as pain, redness, or swelling were reported by 20% to 90% of recipients.

A temperature of 100°F during the 15 days after vaccination was reported in 10% to 13% of HPV vaccine recipients. A similar proportion of placebo recipients reported an elevated temperature. Local reactions generally increased in frequency with increasing doses. However, reports of fever did not increase significantly with increasing doses.

A variety of systemic adverse reactions have been reported by vaccine recipients, including nausea, dizziness, myalgia, and malaise. However, these symptoms occurred with equal frequency among both HPV vaccine and placebo recipients.

Contraindications and precautions

Contraindications and precautions to vaccination generally dictate circumstances when vaccines will not be given.

Human Papillomavirus Chapter of Pinkbook: (Epidemiology and Prevention of Vaccine-Preventable Diseases)